Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Naeem, A.S.; Tommasi, C.; Cole, C.; Brown, S.J.; Zhu, Y.; Way, B.; Willis Owen, S.A.; Moffatt, M.; Cookson, W.O.; Harper, J.I.; Di, W.L.; Brown, S.J.; Reinheckel, T.; O'Shaughnessy, R.F.
    A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis (2017), J. Allergy Clin. Immunol., 139, 1228-1241 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.16 gene CTSH, real-time PCR enzyme expression analysis in skin and keratinocyte culture Homo sapiens
3.4.22.16 gene CTSH, real-time PCR enzyme expression analysis in skin and keratinocyte culture Mus musculus
3.4.22.16 gene CTSH, real-time PCR enzyme expression analysis in skin and keratinocyte culture Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
3.4.22.16 additional information generation of short hairpin RNA Ctsh knockout and heterozygote mice into C57BL/6J background Mus musculus
3.4.22.16 additional information lentiviral shRNA knockdown in human keratinocytes Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.16 lysosome
-
 Homo sapiens 5764
-
3.4.22.16 lysosome
-
 Mus musculus 5764
-
3.4.22.16 lysosome
-
 Rattus norvegicus 5764
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.16 Homo sapiens P09668
-
-
3.4.22.16 Mus musculus P49935
-
-
3.4.22.16 Mus musculus C57BL/6J P49935
-
-
3.4.22.16 Rattus norvegicus P00786
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.16 keratinocyte
-
 Homo sapiens
-
3.4.22.16 keratinocyte
-
 Mus musculus
-
3.4.22.16 keratinocyte epidermal Rattus norvegicus
-
3.4.22.16 additional information immunofluorescent and immunohistochemic analysis Homo sapiens
-
3.4.22.16 additional information immunofluorescent and immunohistochemic analysis Mus musculus
-
3.4.22.16 additional information immunofluorescent and immunohistochemic analysis Rattus norvegicus
-
3.4.22.16 skin
-
 Homo sapiens
-
3.4.22.16 skin
-
 Mus musculus
-
3.4.22.16 skin
-
 Rattus norvegicus
-

Synonyms

EC Number Synonyms Comment Organism
3.4.22.16 CTSH
-
 Homo sapiens
3.4.22.16 CTSH
-
 Mus musculus
3.4.22.16 CTSH
-
 Rattus norvegicus

General Information

EC Number General Information Comment Organism
3.4.22.16 malfunction loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout Homo sapiens
3.4.22.16 malfunction loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout Rattus norvegicus
3.4.22.16 malfunction reduced filaggrin processing and impaired epidermal barrier in CTSH-deficient mouse skin, histology of Ctsh-/-, Ctsh+/-, and wild-type mouse neonatal skin, overview. Loss of CTSH increases skin macrophage counts, mast cell degranulation, and proinflammatory molecule expression. Loss of CTSH inhibits filaggrin processing, but not expression, and impairs epidermal barrier function, evidence for compensation in CTSH knockout Mus musculus
3.4.22.16 metabolism phosphoinositide 3-kinase signaling through AKT1 is required for the proteolytic processing of filaggrin during late epidermal terminal differentiation Homo sapiens
3.4.22.16 metabolism phosphoinositide 3-kinase signaling through AKT1 is required for the proteolytic processing of filaggrin during late epidermal terminal differentiation Mus musculus
3.4.22.16 metabolism phosphoinositide 3-kinase signaling through AKT1 is required for the proteolytic processing of filaggrin during late epidermal terminal differentiation Rattus norvegicus
3.4.22.16 physiological function profilaggrin to filaggrin processing is complex, requiring dephosphorylation and numerous proteolytic events, several proteases have been identified that cleave profilaggrin at specific sites, releasing the filaggrin monomers and both the N- and C-termini, including cathepsin H. CTSH is a differentiation-dependent protease coexpressed with filaggrin Homo sapiens
3.4.22.16 physiological function profilaggrin to filaggrin processing is complex, requiring dephosphorylation and numerous proteolytic events, several proteases have been identified that cleave profilaggrin at specific sites, releasing the filaggrin monomers and both the N- and C-termini, including cathepsin H. CTSH is a differentiation-dependent protease coexpressed with filaggrin Mus musculus
3.4.22.16 physiological function profilaggrin to filaggrin processing is complex, requiring dephosphorylation and numerous proteolytic events, several proteases have been identified that cleave profilaggrin at specific sites, releasing the filaggrin monomers and both the N- and C-termini, including cathepsin H. CTSH is a differentiation-dependent protease coexpressed with filaggrin Rattus norvegicus